Zaroxolyn (Metolazone) is a prescription medication used to treat high blood pressure. This medication is also used to reduce swelling and fluid retention that could result from conditions such as congestive heart failure or kidney disease. Lowering high blood pressure can help prevent strokes, heart attacks, and kidney disorder such as nephrotic syndrome. Metolazone belongs to a class of drugs known as diuretics. It works by preventing your body from absorbing too much salt, which can cause fluid retention and it increases the amount of urine you make which causes your body to get rid of excess water. Lowering high blood pressure can help prevent strokes, heart attacks, and kidney issues

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Seek emergency medical help if you have any signs of an allergic reaction to this medication.

The common side effects of Zaroxolyn may include:
• Constipation or diarrhea;
• Dizziness or drowsiness, spinning sensation, fatigue;
• Feeling depressed;
• Feeling tingly, numbness;
• Loss of appetite, nausea, stomach ache;
• Muscle or joint pain

Contact your doctor immediately if any of these serious side effects occur:
• Chest pain;
• Easy bruising or bleeding;
• Feeling light-headed, like you might faint;
• Fluttering in your chest or pounding heartbeats;
• Liver problems;
• Low levels of sodium in the body;
• Severe skin reaction;
• Signs of electrolyte imbalance;
• Symptoms of low potassium

This is not a complete list of side effects and others may occur. Please call your doctor if you have any further concerns or questions.

Do not use Zaroxolyn if you are allergic to Metolazone or if you are unable to urinate or have severe liver disease. Prior to taking this medication, tell your doctors about your medical history and if you have:
• A heart rhythm disorder;
• An allergy to sulfa drugs;
• An electrolyte imbalance;
• Diabetes;
• Gout;
• Liver or kidney disease;
• Systemic lupus erythematosus

Drinking alcohol with this medication can cause side effects. Avoid becoming overheated or dehydrated during exercise, in hot weather, or by not drinking enough fluids. Tell your doctor about all the medications you take including prescription, nonprescription, herbal products, and vitamins. There may be a drug interaction between Zaroxolyn and other medications. If you have diabetes, this medication may affect your blood sugar. Check your blood sugar regularly. Consult your doctor if you are pregnant or breastfeeding. Zaroxolyn is not approved for use by anyone younger than 18 years old.

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