Sinemet CR (Carbidopa/Leovdopa) is a combination prescription medication used to treat symptoms of Parkinson’s disease such as shakiness, stiffness, and difficulty moving. This condition is caused by too little of a naturally occurring substance in the brain. Levodopa changes into dopamine in the brain, helping to control movement. Carbidopa prevents the breakdown of levodopa in the bloodstream so more levodopa can enter the brain. Carbidopa can also reduce some of levodopa's side effects such as nausea and vomiting. Sinemet CR belongs to a class of drugs called Decarboxylase Inhibitors.

Manufacturer Information

Seek emergency medical help if you have any signs of an allergic reaction to this medication. The common side effects of Sinemet CR may include constipation, dry mouth, dizziness, headache, jerky or twisting muscle movements, lightheadedness, muscle contractions, nausea, unusual dreams, and vomiting.

Contact your doctor immediately if any of these serious side effects occur:
• Confusion, hallucinations;
• Depression or thoughts of suicide;
• Severe or ongoing diarrhea or vomiting;
• Severe nervous system reaction;
• Unusual changes in mood or behavior;
• Uncontrolled facial muscle movements;
• Worsening of tremors

This is not a complete list of side effects and others may occur. Please call your doctor if you have any further concerns or questions.

Do not use Sinemet CR if you are allergic to Carbidopa or Levodopa or if you have narrow-angle glaucoma. Do not use this medication if you have used an MAO inhibitor in the past 14 days. Prior to taking this medication, tell your doctor if you have ever had:
• A hormonal disorder;
• A stomach or intestinal ulcer;
• Asthma or COPD, or other breathing problems;
• Depression, mental illness or psychosis;
• High blood pressure or heart problems;
• Liver or kidney disease;
• Open-angle glaucoma

Drinking alcohol with this medication can cause side effects. Sinemet CR may impair your reactions. Avoid driving or hazardous activity until you know how this medication will affect you. Do not take iron supplements or eat a diet high in protein; this will make it harder for your body to digest and absorb Sinemet CR. Tell your doctor about all the medications you take including prescription, nonprescription, herbal products, and vitamins. There may be a drug interaction between Sinemet CR and other medications. Consult your doctor if you are pregnant or breastfeeding.

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