Proin (Phenylpropanolamine Hydrochloride) is a prescription medication used to treat urinary incontinence in dogs. Proin will not effectively treat dogs with incontinence due to neurologic disease or malformations. The medicine is also used as an extra-label to treat urinary incontinence in cats. Off- or extra-label use means a medication can be used in a way or in a particular species not specified on the medication label. Only a veterinarian with direct and personal knowledge of your pet should prescribe this medicine. This medicine is prescribed off- or extra-label if there are no other appropriate medications for a particular pet's circumstances. The active ingredient in Proin is Phenylpropanolamine Hydrochloride. Phenylpropanolamine Hydrochloride belongs to a class of drugs called sympathomimetic amines. It works by stimulating the smooth muscles of the urethra, bladder neck, and urethral sphincter to increase tone and closing the neck of the bladder.
Manufacturer Information
We currently offer the brand Proin from Canada manufactured by Pegasus Laboratories in the strength of 25 mg, 50 mg, and 75 mg chewable tablets. The generic version is not available.
Get medical help immediately if your dog has any of these signs or an allergic reaction while using Proin. The most common side effects of Proin may include the following:
• Appetite loss;
• Increased thirst;
• Lethargy;
• Panting;
• Vomiting;
• Weight loss
Contact your veterinarian right away if your dog has any of the severe side effects, including:
• Abnormal heart rhythm;
• High or low heart rate;
• Insomnia;
• Irritability;
• Musculoskeletal disorder;
• Restlessness
These are not all of the side effects of Proin. Always contact your veterinarian if you notice any unusual symptoms.
You should not give your dog Proin if it is allergic to Phenylpropanolamine Hydrochloride or any ingredient in Proin. Before you start administering this medication, tell your veterinarian about your dog's medical history, especially if it:
• Has a heart or vessel disorder;
• Has a history of seizures;
• Has an enlarged prostate;
• Has diabetes;
• Has elevated thyroid syndrome;
• Has glaucoma;
• Has high blood pressure;
• Has kidney disease;
• Has musculoskeletal disorders;
• Is lactating;
• Is pregnant or breeding
Tell your veterinarian about all your medications, including prescription, OTC, herbal supplements, and vitamins. There may be drug interactions between the Proin and other medicines, such as sevoflurane, monoamine oxidase inhibitors (MAOIs), nonsteroidal anti-inflammatory drugs (NSAIDs), reserpine, aspirin, etc. Tell your veterinarian if your dog is pregnant, breeding, or lactating. It is unknown if Proin will harm a pregnant, breeding, or nursing dog. Discuss the benefits and risks of administering this drug to a pregnant, breeding, or lactating dog with your veterinarian. Inform your veterinarian if your dog is lactating. Use this medicine exactly as your veterinarian prescribes. Proin comes as a chewable tablet. Give the recommended dose to your dog. Ensure your dog takes the full dose. You can administer this drug with or without food. However, giving the drug with food may prevent digestive system upset. Proin can increase thirst. Provide enough water for your dog after administering the drug. If your dog's incontinence occurs at night, administer the largest dose before sleeping. Proin works almost immediately. You should see improvements in about 1 to 2 hours. This drug is not for humans to use. Wash your hands thoroughly after administering the medication. In case of accidental ingestion, contact your doctor immediately. Monitor your dog's blood pressure regularly when it starts using Proin, then at least twice yearly. Store this drug at room temperature, away from light and moisture. Keep out of the reach of children.