One-Alpha (Alfacalcidol) is a prescription vitamin-D analogue used hypocalcaemia, secondary hyperparathyroidism, and osteodystrophy in patients with chronic renal failure. The body needs calcium for healthy bones and teeth. It is also used to treat the softening and deformity of the bones due to a lack of calcium (rickets or osteomalacia). The active ingredient in One-Alpha is Alfacalcidol. Alfacalcidol belongs to a class of drugs called vitamin D analogues. It works by increasing the amount of vitamin D in the body. Increasing the amount of vitamin D in the body increases calcium and phosphate levels.
Manufacturer Information
We currently offer the brand One-Alpha from Canada manufactured by Leo. The generic Alfacalcidol is also available from Canada by a different manufacturer. They are both available in the strength of 0.25 mcg and 1 mcg tablets.
Get medical help immediately if you have any of these signs or an allergic reaction while taking One-Alpha. The most common side effects of One-Alpha may include the following:
• Abdominal pain;
• Itchy skin;
• Skin rash
Contact your doctor right away if you have any of the severe side effects, including:
• Frequent urination;
• Increased thirst;
• Symptoms of an allergic reaction such as breathing difficulties, hives, or swelling of face, lips, tongue, or throat;
• Weakness or pain in your muscles or bones
These are not all of the side effects of One-Alpha. Always contact your doctor if you notice any unusual symptoms.
You should not take One-Alpha if you are allergic to Alfacalcidol or any ingredient in One-Alpha. Before you start using this medication, tell your doctor about your medical history, especially if you:
• Are breastfeeding or planning to breastfeed;
• Are pregnant or planning to be pregnant;
• Have a condition called calcification;
• Have epilepsy;
• Have hypercalcemia;
• Have kidney problems
Tell your doctor about all your medications, including prescription, OTC, herbal supplements, and vitamins. There may be drug interactions between One-Alpha and diuretics, medicines containing vitamin D, antacids containing aluminum, etc. Avoid phenytoin, digoxin, or cholestyramine with One-Alpha. Tell your doctor if you are pregnant or planning to become pregnant. It is not known if One-Alpha will harm a fetus. Inform your doctor if you are breastfeeding or planning to breastfeed. Alfacalcidol passes into breast milk and may influence calcium metabolism in nursing infants. Take One-Alpha precisely as prescribed by your doctor. Swallow the capsule whole with food or water. Your doctor may carry out weekly blood tests when you start taking One-Alpha to know if your dose is right for you. Your doctor may adjust your dose. Do not stop taking Alfacalcidol without talking to your doctor. Avoid driving or operating machinery until you know how One-Alpha affects you. Keep this medicine in its original container out of sight and reach of children. Store below 250C.
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