Ofev (Nintedanib Esylate) is a prescription medication used to treat lung diseases like idiopathic pulmonary fibrosis (IPF) and chronic interstitial lung disease (ILD) in which lung fibrosis continues to worsen—both types of lung disease scar and stiffen the lungs, causing breathing difficulties. Ofev is also used to slow the rate of decline in lung function in adults with systemic sclerosis-associated interstitial lung disease (SSc-ILD). Ofev is not a cure for IPF or ILD. The medicine slows down the effects of the diseases on your lungs. The active ingredient in Ofev is Nintedanib Esylate. Nintedanib belongs to a class of drugs called tyrosine kinase inhibitors. It works by disrupting the activity of specific types of cell proteins that make scar tissue. If the brain, heart, and other organs do not get enough oxygen, other medical problems can occur.

Manufacturer Information

We currently offer the brand Ofev from Australia and Turkey, manufactured by Boehringer Ingelheim in the strength of 100mg and 150mg capsules. The generic Nintedanib Esylate is also available from India also called Nindanib manufactured by Glenmark in the strength of 100mg and 150mg soft-gel capsules.

Get medical help immediately if you have any of these signs or an allergic reaction while taking Ofev. The most common side effects of Ofev may include the following:
• Appetite loss;
• Diarrhea;
• Headaches;
• Increased blood pressure;
• Nausea;
• Stomach pain;
• Vomiting;
• Weight loss

Contact your doctor right away if you have any of the severe side effects, including:
• Bloody stools or bleeding from your rectum;
• Chest pain;
• Chills;
• Cough with mucus;
• Fever;
• Jaundice;
• Pain spreading to your jaw or shoulder;
• Severe diarrhea;
• Severe ongoing nausea;
• Severe stomach pain;
• Shortness of breath;
• Sudden numbness or weakness

These are not all of the side effects of Ofev. Always contact your doctor if you notice any unusual symptoms.

You should not take Ofev if you are allergic to Nintedanib or any ingredient in Ofev. Before you start taking this medication, tell your doctor about your medical history, especially if you:
• Are breastfeeding or plan to breastfeed;
• Are pregnant or plan to become pregnant;
• Are taking a blood thinner like warfarin;
• Have a blood clot;
• Have a family history of bleeding problems;
• Have heart problems;
• Have kidney problems;
• Have liver disease;
• Have or have had an aneurysm (enlargement and weakening of a blood vessel wall);
• Have or have had stomach surgery

Tell your doctor about all your medications, including prescription, OTC, herbal supplements, and vitamins. There may be drug interactions between Ofev and other medicines, including those used to treat fungal infections, bacterial infections, and drugs that affect your immune system. Avoid rifampicin, phenytoin, carbamazepine, or St. John’s wort with Ofev. Tell your doctor if you are pregnant or planning to become pregnant. Ofev can harm an unborn baby. Women of childbearing potential should use effective contraception while taking this drug and for at least three months after stopping treatment. Ask your doctor for the best method of birth control when taking Ofev. Do not breastfeed when using Ofev. This drug may harm nursing babies. Inform your doctor if you are breastfeeding or planning to breastfeed. Take Ofev precisely as prescribed by your doctor. Swallow the capsules whole with water. Do not chew or open the capsule. Take this drug with food. Keep this medicine out of the sight and reach of children. Do not store Ofev above 250C.

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