Nexlizet (Bempedoic Acid/Ezetimibe)

Nexlizet (Bempedoic Acid/Ezetimibe) is a prescription medicine that contains 2 cholesterol lowering medicines, bempedoic acid and ezetimibe. Bempedoic acid works by reducing the amount of cholesterol made by the liver. Ezetimibe works by reducing the amount of cholesterol your body absorbs from your diet. Nexlizet is used along with diet and other lipid-lowering medicines in the treatment of adults with: heterozygous familial hypercholesterolemia (HeFH) which is an inherited condition that causes high levels of “bad” cholesterol (LDL), known heart disease who need additional lowering of “bad” cholesterol (LDL-C) levels. It is not known if Nexlizet is safe and effective in children under 18 years of age. Take Nexlizet exactly as your healthcare provider tells you to take it. Swallow the Nexlizet tablet whole. Do not cut, chew, or crush the tablet. You may take Nexlizet with or without food. If you take a medicine that lowers cholesterol by binding bile acids, such as colesevelam or cholestyramine, take Nexlizet at least 2 hours before or 4 hours after you take bile acid binding medicines. Ask your healthcare provider if you are not sure if you take these medicines.

Manufacturer Information

The common side effects of Nexlizet may include symptoms of the common cold, flu, or flu-like symptoms, muscle spasms, back pain, stomach pain, bronchitis, pain in shoulder, legs, or arms, anemia, increased liver enzymes, diarrhea, fatigue. Contact your doctor right away if you have any of the following symptoms:

• increased levels of uric acid in your blood, symptoms include severe foot pain especially in the toe joint, tender joints, warm joints, joint redness, swelling;

• tendon rupture or injury. Symptoms include hear or feel a snap or pop in a tendon area bruising right after an injury in a tendon area, unable to move the affected area or put weight on the affected area, pain, swelling, tears, and inflammation of tendons including the arm, shoulder, and back of the ankle

This is not a complete list of side effects and others may occur. Please call your doctor if you have any further concerns or questions.

Do not take Nexlizet if you are allergic to ezetimibe tablets. Ezetimibe, one of the active ingredients in Nexlizet, can cause serious allergic reactions such as anaphylaxis, angioedema, rash, and urticaria. Stop taking Nexlizet, call your healthcare provider or go to the nearest hospital emergency room right away if you have any signs or symptoms of an allergic reaction. Before you start taking Nexlizet, tell your healthcare provider about all your medical conditions, including if you: have or had gout, have or had tendon problems, are pregnant or are breastfeeding, have severe kidney problems, have moderate or severe liver problems. Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements, especially simvastatin or pravastatin (other cholesterol lowering medicines), cyclosporine (often used in organ transplant patients), fibrates (used to lower cholesterol), cholestyramine (used to lower cholesterol).

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