Imvexxy (Estradiol Vaginal Inserts)

Imvexxy (estradiol vaginal inserts) is a prescription medicine that contains an estrogen hormone in a vaginal insert. It is used after menopause to treat moderate to severe painful intercourse and other symptoms such as vaginal dryness, burning or itching due to changes in and around your vagina. Imvexxy restores vaginal tissues and improves your vagina's pH levels to relief your symptoms. Imvexxy provides a sex hormone called estradiol, which is a type of estrogen. Imvexxy is an ultra-low dose estrogen option in a soft gel insert. This medication may help reduce dryness and discomfort around your vagina. After menopause, your body makes less or no estrogen. Imvexxy replaces the estrogen that is missing in some women. It improves pain before, during or after sex, which is a symptom of vulvar and vaginal atrophy. Use Imvexxy exactly as directed by your healthcare professional.

Manufacturer Information

Common side effects of Imvexxy may include headache, dizziness, memory loss; vision changes; abdominal, back and pelvic pain; nausea; diarrhea; feeling bloated; feeling tired (fatigue); change in appetite, body weight; excessive sweating, body odor; vaginal discharge, discomfort, odor; anxiety, feeling nervous; loss of scalp hair; excess hair on face, chest, abdomen or legs; breast tenderness, pain, swelling; acne, rash, itchy skin; pain during sex.

Call your doctor immediately if you notice more serious side effects such as:
• Changes in vaginal bleeding;
• Deep vein thrombosis (blood clot in the legs);
• Nasopharyngitis (a cold): runny or stuffy nose, sore throat, cough;
• Pulmonary embolism (blood clot in the lungs);
• Signs of a stroke (blood clot in the brain);
• Urinary tract infection (infection in urinary system including kidneys, ureters, bladder and urethra)

This is not a complete list of side effects, and others may occur. Contact your doctor if any of these side effects worsen or persist.

Do not use Imvexxy if you are allergic to any ingredients in this drug or the container; are or maybe pregnant or breastfeeding; have or have had liver problems; have, might have or had estrogen-dependent cancers (e.g. endometrial cancer); your uterus lining is thicker than normal; have or have had breast cancer; have unexplained bleeding from the vagina; have recently had a heart attack; have or have had blood clotting problems. To help avoid side effects and ensure proper use, talk to your healthcare professional before you take Imvexxy about any health conditions or problems you may have, including if you have or had uterus problems; have a history of allergy or intolerance to any drugs or other substances; have or had any vaginal bleeding that is not normal; have symptoms of blood blockage to the brain; have or had high blood pressure; have or had asthma; have kidney problems; have seizures (epilepsy); have or had bone disease; have or had diabetes; are pregnant, may be pregnant or breastfeeding. The medicines that may interact with Imvexxy include drugs used to treat diabetes, such as glyburide and insulin; drugs used for the prevention or treatment of blood clots (anticoagulants), such as warfarin; drugs used to treat high blood pressure, drugs that impact liver enzymes; Ritonavir and nelfinavir, used to treat HIV/AIDS; St. John’s Wort, used to treat depression.

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