Holkira Pak (Dasabuvir Sodium/Omitasvir/Paritaprevir/Ritonavir)

Holkira Pak (ombitasvir – paritaprevir – dasabuvir – ritonavir) is a combination of antivirals commonly used alone or in combination with ribavirin to treat chronic hepatitis C, a viral infection of the liver. Ombitasvir, paritaprevir, and dasabuvir directly interfere with the replication of the hepatitis virus, while ritonavir acts only to improve the oral absorption of paritaprevir. The actions of ombitasvir, paritaprevir, and dasabuvir are based on the reduction of hepatitis C virus levels in the body, which aids in the immune system's ability to combat the infection and may aid in liver recovery. Ritonavir is used to raise (or "boost") paritaprevir levels. Holkira Pak does not prevent transmission of the hepatitis C virus through sexual intercourse, or blood contamination, neither does it protect a patient from reinfection with the virus. The product typically contains two tablets: One containing ombitasvir, paritaprevir, and ritonavir, and the other tablet containing dasabuvir.

Manufacturer Information

Holkira Pak may cause tiredness, weakness, nausea, mild itching, or difficulty sleeping. If any of these effects persists or gets worse, inform your doctor or pharmacist promptly.

Check with your doctor as soon as possible if you notice any symptoms of liver dysfunction while taking this drug. They may include:
• Nausea;
• Vomiting;
• Diarrhea;
• Loss of appetite;
• Weight loss;
• Yellowing of the skin or whites of the eyes;
• Dark urine;
• Pale stools

Patients may also develop a rare severe allergic reaction to the medication, which initially presents as a rash or mild reaction. Stop taking the medication and see your doctor immediately if you notice signs of an allergic reaction including:
• Abdominal cramps;
• Difficulty breathing;
• Nausea and vomiting;
• Swelling of the face and throat

You should not use Holkira Pak if you have moderate to severely decreased liver function or if you are:
• Allergic to ombitasvir, paritaprevir, ritonavir, dasabuvir or to any of the ingredients of the medication;
• Pregnant and also taking ribavirin

Before you start using this medication, talk to your doctor about your medical history and if you have a heart rhythm disorder, hepatitis B infection or problems with liver function. You should also inform your doctor about all the medications you take including prescription, OTC, herbal supplements and vitamins. There may be a drug interaction between Holkira Pak and other medications. This medication should be used during pregnancy. Consult your doctor if you are breastfeeding.

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