Endometrin (Progesterone) is a prescription medication used in fertility treatment as part of Assisted Reproductive Technology (ART) for women unable to get pregnant due to a lack of natural progesterone in the body. This medication is used to increase the level of progesterone in women taking fertility treatments because these treatments tend to decrease progesterone levels. The active ingredient in Endometrin is Progesterone. Progesterone belongs to a class of drugs called progestins. It works by increasing the amount of progesterone in the body. Progesterone is a female hormone important for ovulation and menstruation. Progesterone causes changes in the lining of your uterus, making it easier for a fertilized egg to attach to the uterus at the beginning of pregnancy. Progesterone then helps your body maintain the pregnancy.
Manufacturer Information
We currently offer the brand Endometrin from Canada manufactured by Ferring in the strength of 100 mg vaginal insert. The generic Progesterone is not available.
Get medical help immediately if you have any of these signs or an allergic reaction while using Endometrin. The most common side effects of Endometrin may include the following:
• Breast pain;
• Dizziness;
• Headache;
• Mood changes;
• Stomach pain
Contact your doctor right away if you have any of the severe side effects, including:
• Breast lump;
• Signs of an allergic reaction, such as trouble breathing, hives, swelling of the face, lips, or throat;
• Signs of depression, such as sleep problems, mood changes, weakness;
• Sudden vision problems;
• Unusual vaginal bleeding
These are not all of Endometrin's side effects. Always contact your doctor if you notice any unusual symptoms.
You should not use Endometrin if you are allergic to Progesterone or any ingredient in Endometrin. Before you start using this medication, tell your doctor about your medical history, especially if you:
• Are breastfeeding or planning to breastfeed;
• Are pregnant or planning to become pregnant;
• Have a history of depression;
• Have abnormal vaginal bleeding;
• Have asthma;
• Have breast or uterine cancer;
• Have congestive heart failure;
• Have epilepsy;
• Have had a recent tubal pregnancy or incomplete abortion;
• Have high blood pressure;
• Have liver disease;
• Have migraines
Tell your doctor about all your medications, including prescription, OTC, herbal supplements, and vitamins. There may be drug interactions between the Endometrin and other medicines, such as Rifampin, Carbamazepine, Phenytoin, Phenobarbital, St. John's wort, other vaginal products, etc. Tell your doctor if you are pregnant or planning to become pregnant. This drug is considered safe for use in early pregnancy. It is used to supplement progesterone levels, which are essential for maintaining a healthy uterine lining (endometrium) and supporting the developing embryo. Inform your doctor if you are breastfeeding or planning to breastfeed. Using Progesterone when breastfeeding can interfere with milk production. Discuss the benefits and risks of using this medicine when breastfeeding with your doctor.
Use this medicine exactly as your doctor prescribes. Endometrin comes as a vaginal insert. This medicine is for vaginal use only. Do not take it by mouth. Thoroughly wash your hands with soap and water before handling the Endometrin insert. You can insert Endometrin while lying on your back with your knees bent or standing with one foot elevated on a chair or toilet seat. Choose the position that is most comfortable for you. Place the vaginal insert into the applicator. Gently insert the applicator (or the insert itself, if no applicator is used) deep into your vagina. If using an applicator, press the plunger to release the insert. Remove the applicator. Rewash your hands after insertion. If you inserted Endometrin while lying down, remain there for a few minutes to allow the insert to settle. Do not douche or use other vaginal products immediately after inserting Endometrin. Use Endometrin at the same time each day to maintain consistent progesterone levels. Some vaginal discharge is normal with Endometrin use. If you experience excessive or concerning discharge, contact your doctor. Have regular physical exams and self-examine your breasts for lumps monthly while using this medicine. Endometrin may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Store this drug at room temperature, away from light and moisture. Keep out of the reach of children.