Comtan (Entacapone) is used with other medications such as levodopa and carbidopa to treat 'wearing-off" symptoms of Parkinson's disease such as muscle spasms, poor muscle control, stiffness, and tremors. Entacapone belongs to a class of drugs known as COMT inhibitors. This medication works by blocking the COMT enzyme that breaks down the Levodopa in the body; hence increasing the level of Levodopa.

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Seek emergency medical help if you have any signs of an allergic reaction to this medication.

The common side effects of Comtan may include diarrhea, dizziness, drowsiness, dry mouth, nausea, stomach pain, uncontrolled muscle movements, and vomiting.

Contact your doctor immediately if you have any of these serious side effects:
• Agitation, confusion;
• Fast or uneven heartbeats, tremors, feeling like you might faint;
• Hallucinations;
• High fever, sweating;
• Restless muscle movements (eyes, tongue, jaw, or neck);
• Severe or ongoing diarrhea;
• Unexplained muscle pain, tenderness or weakness;
• Unusual thoughts or behavior;
• Very stiff muscles

This is not a complete list of side effects and others may occur. Please call your doctor if you have any further concerns or questions.

You should not use Comtan if you are allergic to Entacapone. Prior to taking this medication, tell your doctors about your medical history and if you have ever had:
• A history of mental illness or psychosis;
• Liver disease;
• Low blood pressure

Some people may have increased sexual urges, unusual urges to gamble, other intense urges while taking Comtan. People who have Parkinson's disease may have a higher risk of skin cancer. Entacapone may impair your thinking or reactions. Avoid driving or hazardous activity until you know how this medication will affect you. Avoid getting up too fast from a sitting or lying position or you may feel dizzy. Get up slowly and steady yourself to prevent a fall. Avoid drinking alcohol; it can increase some of the side effects of Entacapone. Tell your doctor about all the medications you take including prescription, nonprescription, herbal products, and vitamins. There may be a drug interaction between Comtan and other medications. Consult your doctor if you are pregnant or breastfeeding.

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