Amaryl M (Glimepiride/metformin) is a prescription medication used to treat the symptoms of type 2 Diabetes Mellitus. Type 2 diabetes occurs when the pancreas cannot produce enough insulin to manage blood sugar levels. Obesity and physical inactivity are risk factors for Type 2 diabetes. Amaryl M controls high blood sugar and reduces heart attack or stroke. The drug can be used alone or with other diabetes medications. The active ingredients in Amaryl M are Glimepiride and Metformin. Glimepiride belongs to a class of medications called sulfonylureas. It works by releasing the body’s natural insulin to lower blood sugar. Metformin belongs to a class of drugs called biguanides. It works by controlling the amount of sugar in the blood. It also decreases the amount of sugar the body absorbs from food and the amount of glucose the liver produces.

Manufacturer Information

Get medical help immediately if you have any signs or an allergic reaction while taking Amaryl M. The most common side effects of Amaryl M may include the following:
• Dizziness;
• Fatigue;
• Headache;
• Low blood sugar;
• Nausea;
• Upset stomach

Contact your doctor right away if you have any of the serious side effects including:
• Confusion;
• Dark-colored urine;
• Easy bleeding;
• Fever;
• Mood changes;
• Pale or yellowed skin;
• Seizures;
• Unusual weight gain;
• Weakness

These are not all of the side effects of Glimepiride/metformin. Always contact your doctor if you notice any unusual symptoms.

You should not take Amaryl M if you are allergic to Glimepiride, Metformin, or any ingredient in Amaryl M. Before you start taking this medication, tell your doctors about your medical history, especially if you:
• Are breastfeeding or plan to breastfeed;
• Are pregnant or plan to become pregnant;
• Have a severe infection;
• Have an allergy to sulfa drugs;
• Have breathing difficulties;
• Have diabetic ketoacidosis;
• Have ever had glucose-6-phosphate dehydrogenase deficiency (G6PD);
• Have ever had heart disease;
• Have ever had liver or kidney disease;
• Have or have had lactic acidosis;
• Have type 1 diabetes

Tell your doctor about all your medications, including prescription, OTC, herbal supplements, and vitamins. There may be drug interactions between Amaryl M and other medicines, including aspirin, colesevelam, cimetidine, propranolol, and warfarin. The use of Amaryl M in children and adolescents has not been established. Do not give the drug to children younger than 18. Tell your doctor immediately if you become pregnant or think you may be pregnant. Controlling diabetes during pregnancy is important. High blood sugar may result in complications in the mother and child. Inform your doctor if you are breastfeeding while using Amaryl M. contact your doctor immediately if your baby experiences symptoms of hypoglycemia, including extreme drowsiness, seizure, feeding problems, or blue lips. Take Amaryl M precisely as prescribed by your doctor. You may experience hypoglycemia and feel hungry, anxious, and irritable while using the drug. Eat or drink a fast-acting source of sugar like hard candy, crackers, non-diet soda, or raisins to quickly treat hypoglycemia. Your doctor may prescribe a glucagon injection kit to help treat severe hypoglycemia. Let your family or friends know how to administer this injection in an emergency. Undernourishment, diet changes, delayed meals, alcohol use, and exercise can affect your blood sugar levels. Do not change your dose or medication schedule without informing your doctor. Keep Glimepiride/metformin away from the reach and sight of children. Store the drug at room temperature, away from moisture and heat.

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