Xeljanz (Tofacitinib Citrate) is a NEW oral medication used to treat moderate to severe rheumatoid arthritis (RA) in adults who have tried other medicines such as methotrexate without successful treatment of symptoms. Tofacitinib is called a Janus kinases (JAK) inhibitor which works by blocking certain enzymes in the body that affect immune system function. Xeljanz is sometimes taken in combination with methotrexate or other arthritis medicines. Tofacitinib is marketed as Xeljanz and Jakvinus. A prescription is required for ordering Xeljanz.

Manufacturer Information

The most common side effects of Xeljanz include:
• Cough;
• Diarrhea;
• Dry mouth;
• Headache;
• Lower back pain;
• Muscle aches;
• Upper respiratory tract infections.

If you suffer any serious side effects as below, please notify your doctor or pharmacist immediately:
• Confusion;
• Difficult breathing;
• Fainting;
• Pale skin;
• Unusual bleeding or bruising;
• Yellow eyes and skin;

Do not take Xeljanz if you are allergic to Tofacitinib or if you have severe liver problems. Tell your doctor about all the medical conditions you have had before, especially if you have:
• a history of shingles;
• a history of skin cancer or melanoma;
• an active infection such as TB;
• diabetes;
• HIV or AIDs;
• kidney disease.

Tofacitinib may lower the ability of your immune system. It is not known whether Xeljanz will harm an unborn baby. Consult your doctor if you are pregnant or breastfeeding.

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