Scemblix (Asciminib Hydrochloride) is a prescription medication used to treat adults with Philadelphia chromosome-positive chronic myeloid leukemia (Ph + CML) who do not have a genetic difference (mutation) called T315I and who were previously treated with at least two medicines called tyrosine kinase inhibitors. Ph + CML is a type of blood cancer (leukemia) in which the body produces too many abnormal white blood cells. The first phase of this blood cancer is the chronic phase. The active ingredient in Scemblix is Asciminib Hydrochloride. Asciminib Hydrochloride belongs to a class of drugs called tyrosine kinase inhibitors. It works by blocking the action of a protein produced by the abnormal white blood cells and stops their division and growth.
Manufacturer Information
We currently offer the brand Scemblix from Canada manufactured by Novartis in the strength of 20mg and 40mg tablets. The generic Asciminib Hydrochloride is not available.
Side Effects
Get medical help immediately if you have any of these signs or an allergic reaction while taking Scemblix. The most common side effects of Scemblix may include the following:
• Diarrhea;
• Fatigue;
• Nausea;
• Rash;
• Upper respiratory tract infections
Contact your doctor right away if you have any of the severe side effects, including:
• Blurred vision;
• Musculoskeletal pain;
• Palpitations;
• Signs of a serious allergic reaction, including abdominal cramps, breathing difficulties, swelling of the face, mouth, and throat;
• Spontaneous bleeding or bruising
These are not all of the side effects of Scemblix. Always contact your doctor if you notice any unusual symptoms.
You should not take Scemblix if you are allergic to Asciminib Hydrochloride or any ingredient in Scemblix. Before you start using this medication, tell your doctor about your medical history, especially if you:
• Are breastfeeding or planning to breastfeed;
• Are pregnant or planning to be pregnant;
• Have a heart rhythm disorder;
• Have ever had a hepatitis B infection;
• Have hypokalaemia;
• Have intolerance to some sugars;
• Have pancreatitis
Tell your doctor about all your medications, including prescription, OTC, herbal supplements, and vitamins. There may be drug interactions between Scemblix and carbamazepine, fentanyl, ergotamine, chloroquine, warfarin, St. John’s wort, etc. Avoid clarithromycin, itraconazole, cobicistat, mifepristone, or nefazodone with Scemblix. Tell your doctor if you are pregnant or planning to become pregnant. Scemblix can harm a fetus. Your doctor may perform a pregnancy test before prescribing this drug. If you are a woman who could become pregnant, use an effective method of contraception during treatment with Scemblix and for at least 3 days after your last dose. Inform your doctor if you are breastfeeding or planning to breastfeed. It is not known if Asciminib Hydrochloride passes into breast milk or if it may affect a nursing infant. You should not breastfeed while taking Scemblix and for at least 3 days after your last dose. Take Scemblix precisely as prescribed by your doctor. Swallow the tablet whole with a glass of water. Do not crush, break, or chew the tablets. Take Scemblix at least 2 hours after any food and then wait at least 1 hour before eating again. It is best to take this drug at the same time every day to help you remember when to take your medicine. Scemblix is a long-term treatment. Continue taking the drug for as long as your doctor tells you. Keep out of the sight and reach of children. Do not store above 250C.