Norpramin (Desipramine) is a prescription medication used to treat depression. The drug improves sleep, mood, appetite, and energy levels and may restore interest in daily living. Desipramine belongs to a class of medicines called tricyclic antidepressants. It works by blocking the reuptake of neurotransmitters like serotonin and norepinephrine in presynaptic terminals. This increases the concentration of the neurotransmitters for mental balance. Norpramin can be used alone or with other medications.

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Get medical help immediately if you have any of these signs or an allergic reaction while taking Norpramin. The most common side effects of Norpramin may include:
• Dry mouth;
• Increased blood pressure;
• Lack of coordination;
• Loss of appetite;
• Nausea;
• Tingly feeling;
• Vomiting;
• Weakness;
• Weight changes

Contact your doctor right away if you have any of the severe side effects, including:
• Aggression;
• Anxiety;
• Breathing difficulties;
• Hallucinations;
• Hyperactivity;
• Impulsive behavior;
• Mood swings;
• Panic attacks;
• Restlessness;
• Self-harm thoughts;
• Sleeping difficulties;
• Swelling in the face, tongue, or throat

These are not all of the side effects of Desipramine. Always contact your doctor if you notice any unusual symptoms.

You should not take Norpramin if you are allergic to Desipramine, any ingredient in Norpramin, or other tricyclic antidepressants. Before taking this medication, tell your doctor about your medical history, especially if you have:
• A family history of glaucoma;
• A family history of mental conditions like schizophrenia and bipolar disorder;
• Breathing problems like asthma or chronic bronchitis;
• Diabetes;
• Eating disorders;
• Hyperthyroidism;
• Kidney problems;
• Liver problems;
• Recent heart attack;
• Seizures

Tell your doctor immediately if you are pregnant or plan or think you may be pregnant. Desipramine may harm the fetus. Norpramin passes into breast milk and may harm a nursing infant. Do not breastfeed when using this medication. Use Nopramin precisely as prescribed by your doctor. Take a missed dose as soon as you remember, except it is close to the time for your next dose. Do not take a double dose to make up for a missed dose. In case of an overdose, seek immediate medical attention. This drug may make you drowsy. Do not drive, use machinery, or do anything that requires alertness. Desipramine may increase sun sensitivity. Limit sun exposure and avoid tanning booths. Tell your doctor about all the medications you take, including prescription, OTC, herbal supplements, and vitamins. There may be drug interactions between Norpramin and other medicines, including clonidine, digoxin, thyroid supplements, disopyramide, and MAO inhibitors like procarbazine and phenelzine. The safety of Norpramin in children less than 12 years is not established. Store Norpramin at 250C. Excursions are permitted to 150C to 300C (590F to 860F).

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