Myfembree (Relugolix/Estradiol/Norethindrone Acetate) is a prescription medication used to treat heavy menstrual bleeding associated with uterine leiomyomas (fibroids). It is also effective in managing moderate to severe pain in women diagnosed with endometriosis. Endometriosis is a condition in which endometrial tissues are found outside the uterus, resulting in painful menstruation, heavy menstrual flow, and postcoital bleeding. The active ingredients in Myfembree are Relugolix, Estradiol, and Norethindrone Acetate. Myfembree belongs to the class of medication called gonadotropin-releasing hormone antagonists (GnRH antagonists). It works by binding and blocking GnRH receptors in the anterior pituitary gland. As a result, it decreases the release of gonadotropins (i.e., luteinizing hormone, follicle-stimulating hormone), thereby decreasing the downstream production of estrogen and progesterone by the ovaries in women.
Manufacturer Information
We currently offer the brand Myfembree from Canada manufactured by Pfizer in the strength of 40 mg/1 mg/0.5 mg tablet (Available soon). The generic version is not available.
Get medical help immediately if you have any of these signs or an allergic reaction while taking Myfembree. The most common side effects of Myfembree may include the following:
• Abnormal uterine bleeding;
• Body weakness;
• Changes in menstrual period;
• Headache;
• Hot flush, and excessive night sweating;
• Reduced sexual libido
Contact your doctor right away if you have any of the severe side effects, including:
• Severe right upper quadrant pain;
• Sudden unexplained partial or complete loss of vision or double vision;
• Sudden rise in your blood pressure;
• Thought of harming yourself;
• Weakness or numbness in an arm or leg;
• Worsening of your pain or bleeding
These are not all the side effects of Myfembree. Always contact your doctor if you notice any unusual symptoms.
You should not take Myfembree if you are allergic to Myfembree or any ingredient in Myfembree. Before you start using this medication, tell your doctor about your medical history, especially if you:
• Are breastfeeding or planning to breastfeed;
• Are pregnant or planning to be pregnant;
• Have diabetes mellitus;
• Heave heart diseases such as uncontrolled hypertension or heart attack;
• Have a history of depression or mental illness;
• Have kidney disease;
• Have severe migraine headaches with aura;
• Have stroke
Tell your doctor about all your medications, including prescription, OTC, herbal supplements, and vitamins. There may be drug interactions between Myfembree and fezolinetant, mifepristone, and ospemifene. Tell your doctor if you are pregnant or planning to become pregnant. Do not take Myfembree if you are trying to become or during pregnancy. Myfembree may increase the risk of early pregnancy loss. Myfembree can cause decreased or no menstrual bleeding, making it hard to know if you are pregnant. It is unknown if relugolix passes into breast milk. Estradiol and norethindrone may decrease breast milk production. A small amount of estradiol and norethindrone passes into breast milk and may have undesirable effects on a nursing infant. Consult your doctor before breastfeeding. Before taking Myfembree tablets, inform your doctor if you have had an allergic reaction to relugolix, estradiol, norethindrone, or any of the ingredients in Myfembree. It comes as a tablet, and it should be taken once daily. Follow your prescription label and use it as prescribed by your doctor. Swallow the tablet whole with a cup of water. If you missed a pill, take the missed dose of Myfembree as soon as possible the same day and then resume regular dosing the next day. Your doctor will conduct a pregnancy test for you before starting you on Myfembree tablets. It would be best to know that Myfembree is not a contraceptive pill, and it does not prevent you from getting pregnant. Use a barrier contraceptive such as a condom while using Myfembree tablet and a week after stopping it. It is often recommended not to use Myfembree for more than 2 years due to the risk of continued bone loss that may not be reversible. Inform your doctor if there is no improvement in your condition. Store the tablet in a safe place and away from the reach of children.
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