Moduretic (Amiloride/Hydrochlorothiazide) is a combined prescription medication used to treat elevated blood pressure (Hypertension) and to reduce the amount of fluid in people with oedema, swelling of the ankles, feet and legs, and massive ascites due to liver disease resulting in fluid accumulation in the stomach area. The active substances in Moduretic are Amiloride and Hydrochlorothiazide. Moduretic belongs to the class of medication called Thiazide combinations. The combination therapy works by excreting the kidneys more fluid and salt while minimizing potassium loss. This helps reduce high blood pressure and associated swellings in different body parts. In addition, effective treatment of Hypertension prevents stroke, kidney diseases and cardiac arrest.

Manufacturer Information

Get medical help immediately if you have any signs of an allergic reaction while taking Moduretic. The most common side effects of Moduretic may include:
• Constipation;
• Diarrhea;
• Getting tired easily;
• Hyperkalemia;
• Nausea and vomiting

Contact your doctor right away if you have any of the serious side effects, including:
• Chest pain;
• Dizziness and light-headedness;
• Severe diarrhea or constipation;
• Symptoms of allergic reactions such as severe itching, difficulty with breathing and swelling of legs and hands;
• Transient blurred vision

You should not take Moduretic if you are allergic to sulfur medicines, such as hydrochlorothiazide or other allergies. Before you start taking this medication, tell your doctor about your medical history, especially if you:
• Are breastfeeding or plan to breastfeed;
• Are pregnant or plan to become pregnant;
• Have asthma;
• Have gout;
• Have a high level of potassium in the blood (hyperkalemia);
• Have kidney problems;
• Have liver diseases;
• Have lung disease

Moduretic is a tablet and should be taken orally with a cup of water. You should follow your prescription label carefully and use it according to your prescription label. Ask your doctor about the type of exercise you can do while treating Hypertension with a Moduretic. Regular exercise also helps to lower high blood pressure. You should stop drinking alcoholic beverages and smoking cigarettes. Your doctor may advise you to reduce the amount of salt in your diet. To reduce your salt intake, you should avoid using salt in cooking. Moduretic may cause a rise in the level of potassium in your blood. Before using potassium supplements or salt substitutes that contain potassium, consult your doctor. Do not use other antihypertensives with Moduretic. Using multiple medications for the same purpose may worsen your condition. Inform your doctor if there is no improvement in your condition or if it worsens.

Tell your doctor immediately if you become pregnant or think you may be pregnant. It is essential to treat Hypertension during pregnancy; however, not all medications can be used during pregnancy. You should discuss the risks of Moduretic in pregnancy with your doctor. Hydrochlorothiazide passes into breast milk and may affect the child. Discuss the risks and benefits with your doctor before breastfeeding. Inform your doctor about all your medications, including prescription, OTC, herbal supplements, and vitamins. There may be a drug interaction between Moduretic and other medications such as lithium, valsartan, eplerenone, spironolactone, tacrolimus, and captopril. Keep your medication in a cool, dry place where the temperature stays below 30°C.

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