Lioresal (Baclofen) is an antispasmodic agent and muscle relaxer. It is used to treat muscle symptoms such as spasm, pain and stiffness, symptoms of multiple sclerosis, spinal cord injuries, or other spinal cord disorders, as well as cerebral palsy and brain injury. It is given intrathecally (directly into the spinal cord) or orally (by mouth). Lioresal given intrathecally works by blocking monosynaptic and polysynaptic reflexes in the spinal cord, which relaxes and relieves muscle contractions. Lioresal given orally works by acting on the GABA-B receptor in the brain and causing the activity of certain nerves in the brain to decrease, which in turn reduces spasms and relaxes muscles.

Manufacturer Information

The generic Lioresal is available from India also called Liofen manufactured by Sun Pharma and Canada by a different manufacturer. The brand Lioresal is not available at this time. The generic alternative, Baclofen, is available in the dosages of 10 mg and 20 mg tablets.

Common side effects of Lioresal include drowsiness, dizziness, or weakness, headache, sleep problems, nausea or constipation, or urinating more than usual. Contact your doctor immediately if you notice more serious side effects such as weak or shallow breathing, confusion or hallucinations, or a seizure. This is not a complete list of side effects, and others may occur. Call your doctor for medical advice about other possible side effects.

You should not use Lioresal if you are allergic to Baclofen, or if you are taking opioid medications, sleeping pills, muscle relaxers, medication for depression, anxiety, or bipolar disorder, seizure medication, or blood pressure medication. To make sure Lioresal is safe for you, tell your doctor if you have ever had kidney disease, ulcers, epilepsy, Parkinson’s disease, cerebral palsy, rheumatoid disorders, mental disorders such as schizophrenia or bipolar disorder, diabetes, hypertension, or a stroke or blood clot. As well, tell your doctor if you are pregnant or breastfeeding in order to discuss any possible risks. Do not use Lioresal if you need muscle tone for safe balance and movement during certain activities. This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Avoid consuming alcohol. Drinking alcohol with this medication can cause side effects.

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