Komboglyze (Saxagliptin/Metformin) is a prescription medication used to treat type 2 diabetes. Type 2 diabetes is a chronic condition affecting how your body processes blood sugar. This condition occurs when the body does not produce enough insulin or resists insulin. The active ingredients in Komboglyze are Saxagliptin and Metformin. Saxagliptin belongs to a class of medications called DPP-4 inhibitors (dipeptidyl peptidase-4 inhibitors). Metformin belongs to a class of medications called biguanides. Saxagliptin and Metformin work together to increase insulin levels after a meal. They also lower the amount of sugar the body makes. Komboglyze is part of a comprehensive treatment program that includes diet, weight loss, and exercise to control diabetes.
Manufacturer Information
We currently offer the brand Komboglyze from Canada manufactured by AstraZeneca in the strength of 2.5 mg/1000mg, 2.5 mg/500mg, and 2.5 mg/850mg tablets. The generic Saxagliptin/Metformin is not available.
Get medical help immediately if you have any of these signs or an allergic reaction while using Komboglyze. The most common side effects of Komboglyze may include the following:
• Appetite loss;
• Diarrhea;
• Gas;
• Headache;
• Indigestion
Contact your doctor right away if you have any of the severe side effects, including:
• Severe joint pain;
• Signs of an allergic reaction, such as trouble breathing, hives, swelling of the face, lips, or throat;
• Signs of lactic acidosis, such as muscle cramps, vomiting, stomach ache, reduced body temperature;
• Signs of low blood sugar, such as sweating, vision changes, hunger, fast heartbeat, slurred speech
These are not all of the side effects of Komboglyze. Always contact your doctor if you notice any unusual symptoms.
You should not use Komboglyze if you are allergic to Saxagliptin/Metformin or any ingredient in Komboglyze. Before you start using this medication, tell your doctor about your medical history, especially if you:
• Are breastfeeding or planning to breastfeed;
• Are pregnant or planning to become pregnant;
• Have a history of lactic acidosis;
• Have ever had a diabetic coma;
• Have heart problems;
• Have kidney problems;
• Have liver disease;
• Have severe dehydration;
• Have type 1 diabetes
Tell your doctor about all your medications, including prescription, OTC, herbal supplements, and vitamins. There may be drug interactions between Komboglyze and other medicines, like cimetidine, ketoconazole, diltiazem, carbamazepine, ibuprofen, rifampicin, etc. Tell your doctor if you are pregnant or planning to become pregnant. It is unknown if Komboglyze can harm your fetus. This drug should only be used in pregnancy if the benefits outweigh the risks. Inform your doctor if you are breastfeeding or planning to breastfeed. Metformin passes into breast milk in small amounts and may harm your nursing infant. Use this medicine exactly as your doctor prescribes. Komboglyze is a tablet. Swallow the tablet whole. Do not break, crush, or chew them. Take one tablet twice a day or as directed by your doctor. Take this drug with a meal to reduce the chance of a stomach upset. Avoid taking alcohol when taking this drug. Alcohol can increase your risk of lactic acidosis. You can take the drug at the same time every day to help you remember. Taking your drug regularly can help keep your blood sugar under control. Store this drug below 250C. Keep out of the reach of children.