Entresto (Sacubitril and Valsartan) is a NEW approved medication used to treat chronic heart failure (HFrEF, or HF) in certain patients. Entresto belongs to the new drug classed called angiotensin II receptor blocker neprilysin inhibitors (ARNIs). It is a combination of two medications. One is sacubitril, which is a neprilysin inhibitor. The second is valsartan (Diovan), which is an angiotensin II receptor blocker. They work by lowering blood pressure and improving blood flow. It is indicated to reduce the risk of cardiovascular death and hospitalization for heart failure in adult patients with chronic heart failure. A valid prescription is required to purchasing Entresto. Other prescription heart medications include Altace, Aldactone, and Coreg.

Entresto (Sacubitril/Valsartan): first-in-class angiotensin receptor neprilysin inhibitor FDA approved for patients with heart failure (American Health & Drug Benefits, September 2015) - Loretta Fala, found that "sacubitril plus valsartan reduced the risk for death from CV causes by 20%, reduced the risk for hospitalization for heart failure by 21%, and reduced heart failure–related symptoms and physical limitations compared with enalapril."

Manufacturer Information

We currently have the brand Entresto comes from Canada, Australia, and India (also known as Vymada) manufactured by Novartis. Entresto is supplied as unscored, ovaloid, film-coated tablets in several dosages and strengths:

• 24 mg/26 mg (available in quantities of 56, 84, 168 tablets, from Australia and India)
• 24.3 mg/25.7 mg (available in quantities of 30 and 90 tablets, from Canada)
• 48.6 mg/51.4 mg (available in quantities of 60 and 180 tablets, from Canada)
• 97 mg/103 mg (available in quantities of 84 tablets, from India)
• 97.2 mg/102.8 mg (available in quantities of 60 and 180 tablets, from Canada)

Generic Entresto comes from India manufactured by Cipla, also it is known as Azmarda. It comes in the strength of 24 mg/26 mg 84 tablets.

The most common side effects of Entresto include:
• Cough;
• Dizziness;
• Low blood pressure;
• High potassium;

If you suffer any serious side effects as below, please notify your doctor or pharmacist immediately:
• Different breathing;
• Dizziness or lightheaded;
• Extreme fatigue;
• Signs of kidney problems (change in the amount of urine);
• Symptoms of a high potassium blood level (Muscle weakness, irregular heartbeat)

Do not take Entresto if you are allergic to Valsartan/Sacubitril or any ingredients of the medication. Do not take potassium supplements or salt substitutes that contain potassium during Entresto treatment. Tell your doctor about all the medical conditions you have had before, especially if you have:
• Allergies;
• Diabetes;
• If you are dehydrated;
• If you are on a low-salt-diet;
• If you taking some medications such as ACE inhibitors, some medicines contain aliskiren;
• Liver or kidney disease;

Do not take Entresto for at least 36 hours before or after you take an ACE inhibitor medicine. Tell your doctor about all the medicines you are taking including prescriptions and over-the-counter medicines including herbal supplements. Entresto may cause dizzy. Do not drive or do any activities that require alertness until you are sure to perform safely. Entresto can cause fetal harm and should not be taken during pregnancy. It is important to prevent pregnancy while taking this medication. Breastfeeding is not recommended while taking Entresto.

• Why do you need a 36-hour washout with Entresto?
Entresto cannot be combined with an ACE inhibitor, and a 36-hour washout period when switching from an ACEI before starting sacubitril/valsartan.

• Where can I buy Entresto?
You can buy Entresto online from www.CanadianPharmacyKing.com, or by phone, by fax, by mail or email.

• How much does Entresto cost?
Our Canada Pharmacy offers the lowest price for Entresto 24 mg/26 mg 84 tablets from India at $259.99. The cost may vary depend on the dosage, quantities, and countries of suppliers.

• Does insurance cover the cost of Entresto?
Unfortunately, we do not accept any insurance.