Some people, especially women and those who have liver disease taking Combivir develop a condition called lactic acidosis (deep, rapid, difficult breathing, drowsiness, numbness or weakness in the limbs, nausea, vomiting, stomach pain) together with an enlarged liver. If you have any of the symptoms listed above, see your doctor as soon as possible. You should not take Combivir if you: have a very low red blood cell count (anemia) or very low white blood cell count (neutropenia), previously had an allergic reaction to Combivir or to any of the ingredients in the product. Before taking Combivir, inform your doctor if you: are pregnant or breast feeding, are taking ribavirin as it could cause or worsen anemia, are taking interferon, have any drug allergies, had, or you have, any diseases of the kidney, had, or you have, any diseases of the liver, particularly hepatitis B or C infection, had, or you have, very low red blood cell count (severe anemia), very low white blood cell count (neutropenia) or any type of blood disorder.
Tell your doctor, nurse, or pharmacist about all the medicines you take, including drugs prescribed by other doctors, vitamins, minerals, natural supplements, or alternative medicines. Combivir may interact with: acetylsalicylic acid, indomethacin, ketoprofen, naproxen, atovaquone, pyrimethamine, codeine, morphine, methadone, cimetidine, probenecid, clofibrate, vincristine, vinblastine, doxorubicin, clarithromycin to be taken 2 hours before or 2 hours after taking Combivir, interferon, Isoprinosine, ganciclovir, fluconazole, amphotericin, flucytosine, phenytoin, valproic acid, oxazepam, lorazepam, rifampicin, co-trimoxazole (trimethoprim and sulfamethoxazole), dapsone, pentamidine, sorbitol-containing medicines (usually liquids) used regularly.
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