Binosto (Alendronate Sodium Trihydrate)

Binosto (Alendronate Sodium Trihydrate) is a bisphosphonate medication that alters bone formation and breakdown in the body. This can slow bone loss and may help prevent bone fractures. Binosto is used in women to treat osteoporosis caused by menopause. Binosto is also used to increase bone mass in men who have osteoporosis. Binosto works by inhibiting osteoclasts which are responsible for breaking down and reabsorbing bone through a process known as bone resorption. It strengthens bones by slowing down bone loss and allowing osteoblasts (bone-building cells) to work more effectively, improving bone mass.

Manufacturer Information

Common side effects of Binosto may include heartburn, upset stomach, stomach pain, nausea, diarrhea, constipation, bone pain, or muscle or joint pain. Contact your doctor if any of these side effects persist or become severe. Contact your doctor if you notice any more serious side effects including:

• Chest pain;
• Difficulty or pain when swallowing;
• Jaw pain;
• New or unusual pain in your thigh or hip;
• New or worsening heartburn;
• Numbness;
• Pain or burning under the ribs or in the back;
• Severe joint, bone, or muscle pain;
• Signs of low calcium levels in your blood;
• Swelling

This is not a complete list of side effects, and others may occur. Contact your doctor if you notice any side effects not listed above.

You should not use Binosto if you are allergic to alendronate, or if you have low levels of calcium in your blood (hypocalcaemia) or if you have problems with the muscles in your esophagus. To make sure this medication is safe for you, tell your doctor if you have ever had trouble swallowing, problems with your stomach or digestion, hypocalcaemia, a dental problem, kidney disease, or any condition that makes it hard for your body to absorb nutrients from food (malabsorption). Do not use Binosto if you cannot sit upright or stand for at least 30 minutes. Binosto may cause serious problems in the stomach or esophagus. You must stay upright for at least 30 minutes after taking this medication. The Binosto effervescent tablet contains a lot of sodium. Tell your doctor if you are on a low-salt diet before using this form of Binosto. Binosto may cause jawbone problems (osteonecrosis). The risk is highest in people with cancer, blood cell disorders, pre-existing dental problems, or people treated with steroids, chemotherapy, or radiation.

It is unknown whether this medication will harm an unborn or breastfeeding baby. Tell your doctor if you are pregnant, plan to become pregnant, or if you are breastfeeding. Avoid smoking while using Binosto, as it can further reduce your bone mineral density. Binosto is not approved for use in children. Binosto may interact with several medications, especially aspirin or any NSAIDs (nonsteroidal anti-inflammatory drugs) such as ibuprofen, naproxen, celecoxib, diclofenac, indomethacin, meloxicam, and others. Tell your doctor about any medications, vitamins, or herbal supplements you are currently taking or have recently taken in order to reduce the risk of interactions. Avoid taking any other medications for at least 30 minutes after taking Binosto. Some medications may make it harder for your body to absorb Binosto.

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